Tirsana Budhathoki was born on 27th Ashad in Dhading. She has 3 siblings, one brother and two sisters. As for her education and schooling, she started her schooling at Shree Karki Gau Ma Vi, Dhading till 8th grade and then later joined in 9th grade at Shree Achene Higher Secondary School and completed her SLC there. After completing her SLC, she shifted to Manamaiju, Kathmandu with her family. She did her +2 at Man Mohan Memorial College located in Sorhakhutte, Kathmandu and later she pursued her Bachelor in Art.
Trisana Budathoki did some dance trainings for 3 months from the famous Dipak KC and then took some advanced dance classes from Narayan Rijal. In addition she also took some acting classes to make sure those two skills would not be a weak point in her career.
Firstly Trisana Budathoki started her own business by opening her own cold store in Thamel and then started her own café business in Newroad.She then introduced herself with Rudra Kuikel who offered her to feature in a music video. Finally she debut as a model from the song Sarab Piuna Jau by Sworrup Raj Acharya. Later she introduced herself with the Ranjan Rijal who then introduced her with the amazing singer Parshuram Rijal and she then got the opportunity to feature in his song. Soon after her first music video she featured in another music video Ago salkai Mutu Bhitra by Parshuram Rijal. After those two songs she was noticed by many directors. She start to got offers and Trisana has starred in more than 2 dozen songs.
She also starred in some Nepali movies as an actress like The Real Artist, What is Love etc.